The transition zone: an essential functional compartment of cilia
WEBJul 2, 2012 · Many proteins that are mutated in ciliopathies are localized to the transition zone, a compartment of the proximal region of the cilium.
The Ciliary Transition Zone: Finding the Pieces and Assembling …
WEBApr 4, 2017 · The transition zone (TZ) is a specialized ciliary domain present at the base of the cilium and is part of a gate that controls protein entry and exit from this organelle. The relevance of the TZ is highlighted by the fact that several of its components are coded by ciliopathy genes.
The ciliary transition zone: From Morphology and Molecules to …
WEBRecent studies have directed our attention to proteins that localize to the ciliary transition zone (TZ), a small evolutionarily conserved subcompartment that is situated between the basal body and the more distal ciliary axoneme.
Composition, organization and mechanisms of the transition zone…
WEBNov 21, 2022 · Here, we explore the potential molecular mechanisms for how the proximal‐most region of the cilium, termed transition zone (TZ), acts as a diffusion barrier for both membrane and soluble proteins and helps …
Differential regulation of transition zone and centriole proteins ...
WEBJul 16, 2018 · Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding. The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia. Main. Cilia are important for...
The molecular architecture of the ciliary transition zones
WEBJun 1, 2024 · In this review, we explore the molecular architecture of the ciliary transition zone, with a particular focus on recent findings obtained using cryotomography and super-resolution imaging techniques.
The transition zone: an essential functional compartment of cilia
WEBJul 2, 2012 · Many proteins that are mutated in ciliopathies are localized to the transition zone, a compartment of the proximal region of the cilium. The loss of these components can disrupt ciliary functions such as the control of protein entry and exit from the cilium, the possible trafficking of essential ciliary components, and the regulation of ...
The ciliary transition zone: from morphology and ... - ScienceDirect
WEBApr 1, 2012 · Recent studies have directed our attention to proteins that localize to the ciliary transition zone (TZ), a small evolutionarily conserved subcompartment that is situated between the basal body (BB) and the more distal ciliary axoneme.
WEBRecent studies have directed our attention to proteins that localize to the ciliary transition zone (TZ), a small evolutionarily conserved subcompartment that is situated between the basal body (BB) and the more distal ciliary axoneme.
WEBHere, we explore the poten-tial molecular mechanisms for how the proximal-most region of the cilium, termed transition zone (TZ), acts as a diffusion barrier for both membrane and soluble proteins and helps to ensure cil-iary autonomy and homeostasis.