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WEBOpen Heart. is an open access journal by BMJ and BCS, publishing original research in cardiovascular medicine. Open Heart is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from protocols to phase ...
Vitamin K2—a neglected player in cardiovascular health: a …
WEBVitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including increased arterial stiffness, vascular and valvular ...
Four pillars of heart failure: contemporary ... - Open Heart
WEBThe past two decades have heralded dramatic improvements in outcomes for people living with heart failure with reduced ejection fraction (HFrEF).1 The more widespread implementation of disease modifying pharmacological therapies,2 supported by landmark trials of renin-angiotensin system inhibitors3 and beta-blockers4 have improved longevity despite a background of an ageing and increasingly ...
Magnesium for the prevention and treatment of cardiovascular …
WEBMagnesium is an essential mineral found in the body. It is naturally present in many foods and is also available as a dietary supplement.1 It serves as a cofactor in more than 300 enzymatic reactions, such as those responsible for regulating blood pressure, glycaemic control and lipid peroxidation. It is therefore also critical to the cardiovascular system.1 The adult body contains ...
WEBTherefore, magnesium supplementa-tion may have significant cardioprotective effects. Second, magnesium activates the Na–K–ATPase, which may be inhibited by non-glucose fuels such as lactate and free fatty acid in the setting of ischaemia. Third, deficiency in magnesium may also lead to chronic electrical instability.
Authors - Open Heart
WEBOpen Heart is an online-only open access journal dedicated exclusively to publishing cardiology research. The journal aims to provide rapid publication of research through a continuous publication model. As well as publishing definitive articles, Open Heart will consider protocols. All articles published in Open Heart will have been sent for peer review.
Transcatheter mitral valve repair: an overview of current and future ...
WEBThe field of transcatheter mitral valve repair (TMVr) for mitral regurgitation (MR) is rapidly evolving. Besides the well-established transcatheter mitral edge-to-edge repair approach, there is also growing evidence for therapeutic strategies targeting the mitral annulus and mitral valve chordae. A patient-tailored approach, careful patient selection and an experienced interventional team is ...
New score for assessing bleeding risk in patients with atrial ...
WEBBackground Information is needed on bleeding risk factors specific for patients with atrial fibrillation (AF) treated with non-vitamin K oral anticoagulants (NOACs). We aimed to identify risk factors in a large real-world cohort and to derive a bleeding risk score for patients with AF treated with NOACs. Methods From nationwide registries (the Norwegian Patient Registry and the Norwegian ...
Transcatheter tricuspid valve intervention techniques and …
WEBSevere tricuspid regurgitation (TR) is an undertreated common pathology associated with significant morbidity and mortality. Classically, surgical repair or valve replacement were the only therapeutic options and are associated with up to 10% postprocedural mortality. Transcatheter tricuspid valve interventions are a novel and effective therapeutic option for the treatment of significant TR ...
Acute myocarditis caused by COVID-19 disease and following …
WEBCOVID-19: from subclinical myocardial injury to fulminant lethal myocarditis. SARS-CoV-2 gains entry into human cells by binding its cleaved spike protein (S1/S2 and S2ʹ sites) to the ACE2 membrane protein,1 which, can be found on ciliated columnar epithelial cells of the respiratory tract, type II pneumocytes and also cardiomyocytes.2 Since, failed human hearts have a higher percentage of ...
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