Lancaster locally is a home rule-class city in Garrard County, Kentucky, in the United States. It is the seat of its county. As of the year 2020 U.S…Lancaster locally is a home rule-class city in Garrard County, Kentucky, in the United States. It is the seat of its county. As of the year 2020 U.S. census, the city population was 3,901. Located south of Lexington, Lancaster is the site of the Kennedy House, sometimes said to have been the setting for Uncle Tom's Cabin. The Civil War training base Camp Dick Robinson was located nearby.