Sant'Apollinare is a comune in the Province of Frosinone in the Italian region Lazio, located about 120 kilometres southeast of Rome and a…Sant'Apollinare is a comune in the Province of Frosinone in the Italian region Lazio, located about 120 kilometres southeast of Rome and about 50 kilometres southeast of Frosinone. Sant'Apollinare borders the following municipalities: Cassino, Pignataro Interamna, Rocca d'Evandro, San Giorgio a Liri, Sant'Ambrogio sul Garigliano, Sant'Andrea del Garigliano, Vallemaio.