With a population of about 784,283 as of 2020 and an area of 3,715 square miles, the region includes the Syracuse metropolitan area. The New York State Department of Transportation's definition of the Central and Eastern region of New York state includes the counties of Albany, Broome, Chenango, Columbia, Cortland, Delaware, Fulton, Greene, …With a population of about 784,283 as of 2020 and an area of 3,715 square miles, the region includes the Syracuse metropolitan area. The New York State Department of Transportation's definition of the Central and Eastern region of New York state includes the counties of Albany, Broome, Chenango, Columbia, Cortland, Delaware, Fulton, Greene, Herkimer, Madison, Montgomery, Oneida, Onondaga, Oswego, Otsego, Rensselaer, Saratoga, Schenectady, Schoharie, Sullivan, Ulster, and Washington, but does not commit itself to a definition of Central New York.