Regulation of both NF-kB and p53 by PI3-kinase/Akt in AML cells could reduce the apoptotic response to cytotoxic chemotherapy. PI3-kinase inhibition can enhance the cytotoxic effect of Ara-C.

Oleandrin inhibits FGF-2 export, activation of NF-Kβ, phosphorylation of Akt, p70S6K, decreasing mTOR activity. In this first-in-human study, we sought to determine the MTD/recommended phase II dose ...

Protective effects of Ejiao on chronic obstructive pulmonary disease in mice via modulation of the ER/AKT/NF-κB pathway Peer-Reviewed Publication ...

Oleandrin inhibits FGF- 2 export and activation of NF-Kβ and inhibits phosphorylation of Akt. PBI-05204 also inhibits p70S6K, decreasing mTOR activity. In this ongoing study of PBI-05204, we sought to ...