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ascopubs.org7y
Phosphorylation of AKT kinase substrates to predict response to the AKT inhibitor MK2206 in the I-SPY 2 trial in both HER2- and HER2+ patients. - ASCO Publications
Qualifying biomarker analysis was performed on 26 proteins/phosphoproteins in the HER-AKT-mTOR pathway to identify candidate proteins correlated with pCR in the HER2+ and HER2- populations treated ...
Nature14y
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer | British Journal of Cancer - Nature
The activity of the protein kinase Akt is frequently dysregulated in cancer and is an important factor in the growth and survival of tumour cells. Akt activation involves the phosphorylation of ...
Nature20y
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells | Oncogene - Nature
This correlated with an inhibition of nuclear translocation by the YB-1(Ala102) mutant. In conclusion, YB-1 is a new Akt substrate and disruption of this specific site inhibits tumor cell growth.
ascopubs.org6y
FOXO1, an AKT downstream substrate, plays a role as tumor suppressor in HCC pathogenesis. | Journal of Clinical Oncology - ASCO Publications
Overexpression of activated FOXO1 can also delay AKT depended HCC in met/β-catenin FVB mice model. Conclusions: AKT/mTORC1 can be a classic molecular pathway for HCC pathogenesis. Nevertheless, the ...
Medscape4mon
PKB/Akt Phosphorylates p27, Impairs Nuclear Import of p27 - Page 5 - Medscape
Tuesday, February 25, 2025. News & Perspective Drugs & Diseases CME & Education Video Decision Point Drugs & Diseases CME & Education Video Decision Point ...
ALZFORUM4y
Akt substrate, phos Ser/Thr | ALZFORUM
Clonality: polyclonal Host: Rabbit Isotype: IgG Source: US Biological Cat# A1124-50 Formulation: liquid, HEPES, NaCl, BSA, glycerol, Protein A and affinity purified. Immunogen/Epitope. Immunogen = ...