A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

Defining functional groups of apoptosis proteins for a knowledge- and data-driven modeling approach. As decision points in apoptosis signal transduction are under the control of multi-protein ...

Researchers at the University of Cologne have identified the key mitochondrial protein AIFM1 as a central coordinator of ...

Thus, they reflect Bax activity in mitochondria during apoptosis, demonstrating how apoptotic Bcl-2 proteins such as Bax remodel the supramolecular architecture of the MOM shell to further drive ...

Liu, X, Zou, H, Slaughter, C, Wang, X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997;89:175-184 Crossref ...

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, ...

Gluing two particular proteins together tricks the tumors into destroying themselves. Cells in our bodies naturally die off in a process called apoptosis, to be replaced by others.

It involves protein regions called NACHT domains, which appear in some animal apoptosis proteins. NACHT domains also exist in bacteria. In fact, in the wild, the microbes that have the most NACHT ...

This showed that the related proteins, even though they were very diverse, were able to substitute for the four lost yeast apoptosis proteins. "This surprising finding suggests that ancient mechanisms ...