A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, ...

BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as BAX and BAK, while ...

Liu, X, Zou, H, Slaughter, C, Wang, X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997;89:175-184 Crossref ...

Researchers at the University of Cologne have identified the key mitochondrial protein AIFM1 as a central coordinator of ...

How protein modifications influence apoptosis. Lomonosov Moscow State University. Journal Trends in Cell Biology DOI 10.1016/j.tcb.2017.01.003. Keywords ...

Gluing two particular proteins together tricks the tumors into destroying themselves. Cells in our bodies naturally die off in a process called apoptosis, to be replaced by others.

Thus, they reflect Bax activity in mitochondria during apoptosis, demonstrating how apoptotic Bcl-2 proteins such as Bax remodel the supramolecular architecture of the MOM shell to further drive ...

This showed that the related proteins, even though they were very diverse, were able to substitute for the four lost yeast apoptosis proteins. "This surprising finding suggests that ancient mechanisms ...

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers The cover for issue 61 of Oncotarget features Figure 4, 'The influence of stress conditions on API-5 ...