Here we show that p53 protein is physically associated with tubulin in vivo and in vitro, and that it localizes to cellular microtubules. Treatment with vincristine or paclitaxel before DNA-damage ...

New research shows that p53 is able to suppress accumulated DNA damage at telomeres. This is the first time this particular function of p53 has ever been described and shows yet another benefit of ...

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer.

DNA damage is carried over in p53-depleted cells from one cell cycle to the next. In p53-proficient cells, low levels of DNA damage after WEE1 inhibition are tolerated as cells manage to repair the ...

p53 is stimulated when DNA is damaged, and the gene triggers a series of responses that attempt to repair the affected DNA. The greater the damage to the DNA, the more p53 becomes activated, and ...

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer.

Minimal induction of DNA damage now resulted in p53‐facilitated apoptosis, but regulation of pluripotent gene expression remained p53‐independent.

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer.

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

Results. The study results showed that even when DNA damage was present, ABS did not considerably affect p53. On the other hand, camptothecin robustly caused p53 protein upregulation, indicating ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...