Insulin/growth factor-mediated FoxO protein degradation is triggered by the phosphorylation of FoxO proteins by Akt (Matsuzaki et al., 2003; Plas and Thompson, 2003; Aoki et al., 2004; Huang et al ...

JNK can also mediate the interaction between insulin and oxidative-stress signalling. AKT/PKB phosphorylation of FoxO induces FoxO binding to 14-3-3 proteins and subsequent nuclear export, whereas ...

Activated (phosphorylated) Akt phosphorylates FOXO, ... Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab 2005;288:E585-E591. Crossref ...

A team led by researchers from the Institute for Diabetes, Obesity and Metabolism (IDOM) at the Perelman School of Medicine, University of Pennsylvania, has overturned a "textbook" view of what ...

When Akt is not present, another gene, Foxo, is on all the time, and the liver "thinks" the body is fasting. In response, glucose production stays on to keep cells supplied in energy-rich molecules.

The researchers examined the two cell signaling pathways that are activated by insulin signaling – the MAPK and AKT pathways. The AKT branch inactivates the forkhead box O (FOXO) transcription factor, ...

More information: Yoshinori Takeuchi et al, FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin, iScience (2021). DOI: 10.1016/j.isci.2021.103446 Journal ...

The protein kinase Akt promotes cell survival by phosphorylating and inhibiting FOXO forkhead transcription factors. FOXO factors have been linked to stress responses and the regulation of longevity.

The Drosophila Forkhead transcription factor FOXO mediates reduction in cell number associated with reduced insulin signaling Martin A. Jünger, Felix Rintelen, Hugo Stocker, Jonathan D. Wasserman ...

Foxo is widely expressed throughout the body (both in flies and in humans), particularly in muscle, the liver and pancreas -- and can regulate many aspects of metabolism in response to insulin ...

Study published in Cell shows that the hormone inhibits a master gene regulator protein of the Phase 2 detoxification pathway. Researchers at the Joslin Diabetes Center found that insulin has a ...

More information: Hae-Eun H. Park et al, A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling, Nature Communications (2021). DOI ...