Here we show that p53 protein is physically associated with tubulin in vivo and in vitro, and that it localizes to cellular microtubules. Treatment with vincristine or paclitaxel before DNA-damage ...

Myc and E2F1 induced p53 and cell cycle arrest even after silencing of p14ARF using short-interfering RNA. Treatment with the ATM/ATR kinase inhibitor caffeine prevented p53 accumulation upon ...

In the absence of p53, the cells remains alive and become cancerous." The study's findings help explain the interlocking roles of MYC, TEL2, and p53 in the development of B lymphoma.

As a key survival signaling pathway, the MDM2/p53 axis is widely involved in the development of many tumors. Preclinical and clinical trials provide evidence to support the notion that inhibition ...

MYC master oncoprotein levels were markedly decreased by treatment. 52 In a subsequent report, a 100% response rate was observed in 21 patients with TP53-mutated/deleted MDS and AML. 127 Interestingly ...

McArthur and his colleagues tested their hypothesis in a mouse model of Myc-driven lymphoma and found that treatment with ... lymphomas was associated with loss of the function of p53, ...

His particular focus is on the Myc protein, ... UK Manchester Institute is researching a protein that plays an important role in stopping cancer developing, the p53 protein.

Well-known disordered proteins that can contribute to cancer—including c-Myc, p53 and K-RAS—have proved too elusive. But this picture is starting to change.

The patients were divided into two groups according to the final pathology: Group 1, Gleason score 6 (ISUP 1, n = 17) and Group 2, Gleason score 7 (ISUP 2 or 3, n = 20). The expression of proteins p53 ...

MYC has been known to be very difficult to target. ... The domains that 5D4 targets are responsible for regulating E2F1, mutant p53, MYC and a process called homologous recombination.

MYC proteins also show an activity that was previously unknown – and which is now opening new doors for cancer research: They form hollow spheres that protect particularly sensitive parts of ...

Mice lacking a copy of Myc develop less severe osteoarthritis with age than wild-type mice. SEDIVY LAB, BROWN UNIVERSITY For many years, researchers have studied the transcription factor MYC, which ...