Notch signaling pathway keeps immature T cells on the right track. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2013 / 11 / 131122165451.htm ...

The key transducer of the Notch-signalling pathway is a DNA-binding protein, CSL (CBF1, Su(H) and LAG-1) (c). CSL is similar to the Rel family of transcription factors.

The Notch signalling network is highly conserved in Metazoa and is crucial for various cell-fate decisions. Focusing onDrosophila melanogaster, this Review summarizes and integrates various recent ...

Notch signalling is involved in the cell-cell communication process via influencing the patterns of gene expression and differentiation. Notch pathway maintains stem cell populations and regulates ...

Previous work by the team had shown that the NOTCH signaling pathway played a central role in differentiation, which is essential for an effective immune response by CD8 + T cells.

Because the Notch signaling pathway is very similar in mice and humans, Kuang sees the results as having important implications for treating obesity and Type 2 diabetes in humans. Type 2 diabetes, ...

The Notch signaling pathway, present in insects, worms and vertebrates, is involved in embryonic patterning as well as nervous system and cardiovascular development.

The Notch pathway is a highly conserved signaling circuit with a critical role in cell-fate determination and tumor initiation. Notch is reported to regulate various key events in tumor ...

NOTCH signaling influences these traits through interactions with other pathways like TGF-β, WNT, and hypoxia signaling. The canonical NOTCH pathway maintains resistant cell populations, while ...

The authors wondered whether Notch signaling could be playing a role in EC-mediated chemoresistance of AML cells. Using their RNA-seq data, they found that Notch-receptors were expressed regardless of ...

The Notch pathway is an ancient, evolutionary conserved signaling mechanism that controls cell-fate decisions and proper morphogenesis of most organs, including teeth. Want more breaking news?

Nature is thrifty. The same signals that embryonic cells use to decide whether to become nerves, skin or bone come into play again when adult animals are learning whether to become afraid.