In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing ...

Here we show that p53 protein is physically associated with tubulin in vivo and in vitro, and that it localizes to cellular microtubules. Treatment with vincristine or paclitaxel before DNA-damage ...

Baylor College of Medicine. "p53 mutations in 10,000 cancer patients shed new light on gene's function." ScienceDaily. www.sciencedaily.com / releases / 2019 / 07 / 190730141834.htm (accessed June ...

p53 mutations in cancer patients shed light on gene’s function. Molly Chiu. 713-798-4710. Houston, TX - Jul 30, 2019. Share this article. Media Component. Content. One of the most extensively studied ...

How P53 Mutations Link To High-grade Breast Cancer, Poor Outcomes. ScienceDaily . Retrieved June 4, 2025 from www.sciencedaily.com / releases / 2009 / 04 / 090419170022.htm ...

The 13 patients whose tumors showed both overexpression of p53 and mutations in TP53 had a rate of progression-free survival at five years of 8±7 percent, as compared with 32±9 percent in the 25 ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53 are a hallmark of most human cancers and cause dramatic defects in p53 function.

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfill its task. Until now, researchers have assumed that the process is the same with all mutation types.

Mutations in the p53 tumor suppressor gene have been implicated in tumor formation: some give rise to a loss-of-function whereas the majority of mutations result in a gain-of-function.

T cells targeting p53 hotspot mutations can be harvested from peripheral blood of patients with metastatic solid epithelial cancers, according to results published in Clinical Cancer Research, a ...