p53 is a central integrator of a plethora of signals and outputs these signals in the form of tumor suppression. It is well accepted that ubiquitination plays a major part in p53 regulation.

The tumor suppressor p53 is tightly controlled at low levels in cells by constant ubiquitination and proteasomal degradation. In response to stresses, ubiquitination of p53 is inhibited through ...

It is also known that ubiquitination of p53 by E6AP and E6 is a major cause of cervical cancer. However, the mechanism of p53 ubiquitination by the interaction of E6AP and E6 proteins remains unclear.

Background: Exposure of a wide variety of wild type and mutated p53 cancer cells to a 28 aa peptide (p28) derived from azurin, a redox protein secreted from the opportunistic pathogen Pseudomonas ...

Paired with MDM2, also known as HDM2 in humans, the two proteins completely degrade p53 in a laboratory model. This is a process known as poly-ubiquitination, which means a specific protein ...

Background: A 28 aa peptide (p28) derived from azurin, a redox protein secreted from the opportunistic pathogen Pseudomonas aeruginosa, preferentially enters a wide variety of cancer cells and ...

Ubiquitination, a fundamental post-translational modification, plays a pivotal role in protein stability, cellular signaling, and gene expression, particularly in the context of CSCs.

Ubiquitination is a relatively common process in humans. Approximately 3 % of the human genome, or more than 600 E3 ligase genes, are involved in ubiquitination's diverse range of biological ...

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the ''guardian of the genome'' for its ability to repair DNA damage or destroy cancerous cells.

Jan 17, 2024: Researchers observe what ubiquitination hinges on (Nanowerk News) Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters ("Structural ...