A new cancer drug candidate has demonstrated the ability to block tumor growth without triggering a common and debilitating ...

Ras proteins have long been the focus of cancer research because of their role as "on/off switch" signaling pathways that control cell division and failure to die like normal, healthy cells do.

Mutant RAS, they found, helps to kick off a series of events involving the transport of specific nuclear proteins that lead to uncontrolled tumor growth, according to a study published November 11 ...

Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras protein, which acts as a molecular switch for cell growth and is involved in the development of cancer.

This research on these protein clusters, or aggregates as scientists call them, ... Supercomputing simulations crucial to the study of Ras protein in determining anticancer drugs.

Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy.

Ras proteins act as a molecular "switch," flipping between active and inactive modes; they play a critical role in cell signaling and growth regulation and are often mutated in cancers.

Mutant RAS helps release EZH2 from a protein complex transported from the nucleus to the cytoplasm. Once released, EZH2 facilitates the breakdown of the DLC1 tumor suppressor protein, leading to ...

Ras genes encode proteins known as signaling molecules. These molecules trigger cells to grow, proliferate and move around the body. They can be turned on or off, except when there are mutations ...

This finding is significant because it could shift the approach to treating cancers driven by RAS gene mutations.Instead of passively blocking RAS — which has been the go-to method to date — this new ...

Ras proteins were originally identified as oncogenes able to induce cell transformation. Since then they have been shown to regulate distinct signaling pathways and induce the proliferation ...

Mutant RAS, they found, helps to kick off a series of events involving the transport of specific nuclear proteins that lead to uncontrolled tumor growth, according to a study published Nov. 11 ...