Insulin Signaling. EPCs obtained from Zucker fatty rats were much more resistant to insulin as measured by Akt phosphorylation when compared with SD rats at various escalating doses of insulin ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF ...

TNF Pharmaceuticals, Inc. (Nasdaq: TNFA) (“TNFA” or the “Company”), a clinical stage biopharmaceutical company committed to developing novel oral ther ...

The resulting paper, "Early tumour necrosis factor antagonist treatment prevents perianal fistula development in children with Crohn's disease: Post-hoc analysis of the RISK study," appeared in Gut.