WHO/ISUP grade correlated with tumor stage (P < 0.005), recurrence (P = 0.02), and progression in stage (P = 0.031). Normal urothelium showed CK20 immunoreactivity restricted to a few umbrella cells.

In a case series of 25 men who underwent primary radical prostatectomy without prior biopsy after an imaging-based diagnosis via multiparametric MRI and prostate-specific membrane antigen PET ...

Ideally, patients would be diagnosed at ISUP grade 2, which is considered "clinically significant." How exactly to hit this sweet spot remains unclear, however, prompting the present study.

Gleason pattern 4 or 5 prostate cancer at a positive surgical margin (PSM) following robot-assisted radical prostatectomy predicts early biochemical recurrence (BCR) of disease, according to study ...

Men with SVI, more than 2 positive nodes, and ISUP grade group 4-5 (vs grade group 2-3) disease had significant 2.1-, 2.6-, and 5.1-fold increased odds of PSA persistence, respectively, compared ...

The primary outcome was detection of clinically insignificant (International Society of Urological Pathology [ISUP] grade 1) prostate cancer; detection of clinically significant (ISUP grade ≥2 ...