Gleason/ISUP grading using H&E has been useful for evaluating the risk of post-prostatectomy clinical recurrence (CR) and biochemical recurrence (BCR) in patients with prostate cancer.

Background: Since the new 2014 grading system was recommended by the International Society of Urological Pathology (ISUP), it has been validated in patients with localized prostate cancer (PCa) and ...