Our structural studies demonstrate that upon dsDNA binding, cGAS is activated through conformational transitions, resulting in formation of a catalytically competent and accessible nucleotide binding ...

This process (Panel B, 2) results in the expression of cGAS and subclasses of transposable elements that are converted to double-stranded DNA (dsDNA) in the cytosol (Panel B, 3).

Existing structures of the mouse cGAS-DNA complex provide a model for enzyme activation but do not explain why human cGAS exhibits severely reduced levels of cyclic GMP-AMP (cGAMP) synthesis compared ...

The cGAS-STING signaling pathway, ... The team discovered that the presence of double-stranded DNA (dsDNA) from compromised or deceased cancer cells triggers the cGAS-STING pathway.

About cGAS. cGAS is an intracellular pattern recognition receptor that is activated after binding to double-stranded DNA (dsDNA) in the cytoplasm.

About cGAS cGAS is an intracellular pattern recognition receptor that is activated after binding to double-stranded DNA (dsDNA) in the cytoplasm.

Pilot screen with 1600 diversity compounds (Life Chemicals): cGAS was used at 10 nM, compounds were at 10 µM; 60 min reaction; negative controls lacked dsDNA (required for cGAS activation); Z = 0 ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens, T ...

Targeting cGAS might provide a promising therapeutic strategy for improving cardiac function in patients with CA. Source: Compuscript Ltd. Journal reference: Wang, R., et al. (2025).

Ventus Therapeutics to Present Phase 1 Results for VENT-03, a First-in-Class cGAS Inhibitor, at LUPUS 2025. VENT-03 was well tolerated across dose cohorts. ... (dsDNA) in the cytoplasm.