In early embryos, loss of Akt activity after overexpression of PTEN or dominant-negative (DN) PI3K results in ectopic apoptosis (Scanga et al., 2000) and experiments using genetic mutants suggest ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K ...

Conclusions: Incubation of CLL cells with the anti-ROR1 mAb induced apoptosis of CLL cells. Apoptosis was preceded by dephosphorylation of PI3K, AKT and mTOR proteins indicating deactivation of these ...

Background: Research of targeted therapies about PI3K/Akt/mTOR pathway have became a hotspot recently,and related researches have been extended from a single-target suppression to multiple-targets ...

Research Progress on Signaling Pathways of LGALS1 in Malignant Tumors. Journal of Biosciences and Medicines, 13, 142-155. doi: 10.4236/jbm.2025.136013 . Malignant tumors, commonly referred to as ...

BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...