The compound provides non-opioid pain relief by targeting neurotensin receptor 1 (NTSR1) on sensory neurons and within the ...

In both mouse models, injections of the modified compound eliminated touch hypersensitivity. For many pain relievers, particularly opioids, tolerance to the medications over time can limit their ...

In both mouse models, injections of the modified compound eliminated touch hypersensitivity. For many pain relievers, particularly opioids, tolerance to the medications over time can limit their ...

As with other substances, you can build up a tolerance to weed. But that’s not always a bad thing, though it’s worth knowing when to wean off. Weed contains the psychoactive compound ...

In some cases, we have the flexibility to design a new compound, where the chemical composition and crystal structure can be engineered with defect tolerance in mind. Benign defect complexes.

the researchers found evidence that repeated use of the compound does not produce a tolerance like opioid pain relievers do, in which ever-higher doses are needed to achieve the same effects.

"The compound SR-17018 is the first biased agonist of the mu opioid receptor that does not lead to tolerance with chronic use," says Stahl, a senior staff scientist in the Bohn lab. "This is a ...