C&EN

Process Development of the Novel LpxC Inhibitor T-1228. Part 1: Synthesis of the Diol Fragment

Toyama Research and Development Center, FUJIFILM Toyama Chemical Co., Ltd., 4-1, Shimookui 2-chome, Toyama 930-8508, Japan ...
IEEE

Multimodal Contrastive Learning for Protein–Protein Interaction Inhibitor Prediction

Abstract: Protein-protein interactions (PPIs) are crucial for various cellular activities and disease development, and modulating PPIs using small molecule inhibitors (PPIIs) has gradually become a ...
The Lancet

Efficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus two NRTIs in adults naive to antiretroviral therapy (DOMINO): 24-week results from a randomised phase 2b study

gInterdisciplinary Immunological Outpatient Clinic, Centre for Sexual Health and Medicine, Department of Dermatology, Venereology and Allergology, Ruhr Universität Bochum, Bochum, Germany ...
FierceBiotech

Tvardi's STAT3 inhibitor flunks phase 2 IPF trial amid high dropout rates

Tvardi Therapeutics has failed its first big test as a public company. Months after joining the Nasdaq, the biotech has reported the unappetizing mix of high dropout rates and placebolike efficacy in ...