Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

A new review brings to light the pivotal role of ribonucleases (RNases) in shaping the molecular foundation of Mendelian ...

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

Ovarian cancer (OC) remains the deadliest gynecologic malignancy, with platinum-based chemotherapies such as carboplatin ...

Therefore, dust fall microplastics inhibited autophagy and induced apoptosis via activating the PI3K/Akt/mTOR pathway, increasing the Bax/Bcl-2 and Cleaved Caspase-3/Caspase-3 ratios. Here we provide ...

Sinigrin decreased mTOR/PI3K/AKT mRNA expression in mice stimulated by DEN. Therefore, suppression of the mTOR/PI3K/AKT signaling pathway hinders the proliferation and infiltration of HCC cells by ...

Keywords: monocrotaline, hepatotoxicity, autophagy, PI3K/Akt/mTOR signaling pathway, apoptosis. Citation: Guo Y, Yuan Y, Wang R, Bai J, Jia Y, Qiu X, Niu H, Li L, Luo Y, Zhao B and Zhang Z (2024) ...

to explore the inhibitory effect of total flavonoids of Polygala fallax Hemsl (PFHF) on human ectopic endometrial stromal cells (HEcESCs) and its mechanism.The potential targets and pathways of PFHF ...