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GABA: 5 Health Benefits for Stress, Sleep, and Mood
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#temazepam #Restoril #pharma #educational #gaba Dr. leo sternbach synthesized valium which was a precursor to temazepam so i credit him. also bc he revolutionized benzo pharma science 🤷♂️
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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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GABA!!! Two big distinctions here— positive allosteric modulators (benzos) vs direct agonists (anesthetics like propofol or alfaxalone). Disinhibitions occurs because downstream neurons are not receiving inhibitory signals anymore (because that presynaptic neuron is inhibited by our drug while normally it releases GABA to calm downstream neurons). neuropharm is so juicy. #fyp #gaba #vetmed
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